Office: 525 Psychology Laboratory Web Site Home Page
Professor, Department of Psychology
Ph.D. 1988, University of Florida
My research focuses on the actions of neurotransmitters, particularly catecholamines and select neuropeptides, in the regulation of behavioral state and state-dependent cognitive processes (working memory, attention). Currently there are 3 main themes: 1) The Neurobiology of Cognitive Enhancers used in the Treatment of ADHD (primarily psychostimulants such as methylphenidate/Ritalin); 2) The Neurobiology of Waking and the Neural Mechanisms Psychostimulant-Induced Arousal; 3) The Neurobiology of Stress and Stress-Related Impairment in Cognitive Function. We take a multidisciplinary approach that includes anatomical, neurochemical, behavioral, electrophysiological and computational methods. This includes examining the effects of cognitive enhancers and stress on the electrophysiological/spiking neuronal activity within the PFC and frontostriatal networks in animals engaged in PFC-dependent cognitive tasks.
Berridge CW and Waterhouse BD (2003) Modulatory Actions of the Locus Coeruleus-Noradrenergic System on Behavioral State and State-Dependent Cognitive Processes. Brain Research Review 42:33-84.
España RA, Reis KM, Valentino RJ, and Berridge CW (2005) Organization of Hypocretin Efferents to Locus Coeruleus and Basal Forebrain Arousal-Related Structures. Journal of Comparative Neurology, 481:160-178. PDF
Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AFT, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry, 60:1111-1120.
Devilbiss DM, Berridge CW (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsivity. Biological Psychiatry, 64:626-635. PDF
Stalnaker TA, España RE, Berridge CW. (2009) Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala. Synapse, 63:82-85. PDF
Berridge CW, Devilbiss DM (2010) Psychostimulants as Cognitive Enhancers: The Prefrontal Cortex, Catecholamines and Attention Deficit Hyperactivity Disorder. Biological Psychiatry, 69: e101- e111. PDF
Spencer RC, Klein, R, Berridge CW (2011) Psychostimulants Act within the Prefrontal Cortex to Improve Cognitive Function. Biological Psychiatry, doi:10.1016/j.biopsych.2011.12.002. PDF
Berridge CW, Schmeichel BE, España RA (2012) Noradrenergic regulation of sleep/wake state. Sleep Medicine Reviews, 16:187-197. PDF